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Immune protection... fights infection

Zinc'd contains the top 3 supplements for immune health* in one capsule: zinc, vitamins C & D3 helping fight bugs

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sense* mission

*Based on the weight of scientific evidence zinc, vitamins C & D are recommended by scientists to have the strongest evidence of immune support.  Our mission is to improve the Nation’s immune health using zinc’d. Helping lift lock-down in time for Christmas and donating ALL PROFITS to a keyworker charity 

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Discover How  To Maximize Immune Protection

From birth we encounter viruses and other infections daily. But our immune system deals with them by creating antibodies. It’s called our innate immune response.

As we get older our immune system is weakened by age, disease, diet and lifestyle. So provides a weak response to viruses and bacterial infection.

Unsurprisingly, it is your age or underlying health conditions or weight or unhealthy lifestyle that dictates who is worst affected by the coronavirus.  

Along with the BAME communities and the poorest in society,  ALL seem to have something in common…a compromised immune system

When something is going around, your immune system is your best defence

sense* has ‘followed the science’

We identified in March

  • 3 key nutrients our immune system needs …no 1 Zinc
  • 3 vital components to fight infection …no 2 vitamin C
  • 3 things we don’t get enough of in our diet…no 3 Vitamin D

And had confirmed in April in an article in the British Medical Journal that

  • Zinc, vitamins C and vitamin D are the top 3 nutrients with the strongest evidence for immune support (see What the Experts Say below)

In July 2020 a clinical study in Germany proposed the widespread use of Zinc to counter COVID-19

  • highlighting deficiency in  Zinc in people with underlying health issues
  • Zinc deficiency in groups “at risk” of poor COVID outcomes
  • supplementation of Zinc reduces severity of symptoms, the frequency and duration of respiratory tract infections

More recently 2 pilot clinical trials in Spain highlighted

  • widespread vitamin D  deficiency in acute COVID patients
  • taking vitamin D reduced ICU entry for COVID patients by 25 times
  • no deaths occurred in the group taking vitamin D compared to 8% without it

Whilst in China a pilot clinical study at Wuhan University Hospital

  • reduced the death rate in COVID patients taking high dose vitamin C by two-thirds

So you can be sure that your immune system needs these 3 nutrients on a daily basis to function properly. Does yours?

Why do I need zinc’d?

 

What makes Zinc, vitamins C and D3 so important?

ZincReduces viral shedding (stops viruses from within a cell). Research has shown that zinc reduces the enzyme RNA polymerase which stops replication of infection (seeWhat the Experts Say” below).

vitamin CAs an antioxidant, it reduces inflammation, improves healing and is vital for balancing the immune system. Helping to calm over reactions such as cytokine or bradykinin storms.

Vitamin C deficiency results in impaired immunity and higher susceptibility to infections (see “What the Experts Say” below)

Vitamin DMultiple studies show that optimal vitamin D levels are important for immune health. Affecting both the innate and adaptive immune systems (see “What the Experts Say” below).

Scientists are calling for its use in combatting the public health response to the current pandemic.

Even the mainstream media such as the Daily Mail and Daily Telegraph are calling on the Government to implement its widespread use.

Why Am I Not Getting Enough of these Ingredients?

Zinc

We don’t make our own zinc and most people don’t consume enough in their daily diet to meet the required amount needed. What we eat, we do not store well and as you get older, you don’t absorb enough zinc to allow for proper immune function.

Vitamin C

We also don’t make our own vitamin C and 50% of the vitamin C that we absorb from the foods we digest is used up in the first 30 minutes. So without constantly eating fruit and vegetables, we need to take vitamin C supplements. Otherwise it is likely periods of deficiency will occur.

Vitamin D

UK Government advice says everyone should take a Vitamin D supplement especially over winter. We don’t get enough sunlight to make enough vitamin D ourselves leading to comprised immune efficiency.

Why zincd by sense*

sense* was founded on a personal mission by Jonathan Ebsworth. He overcame personal adversity with his own health and was determined to pass on the lessons he had learnt.

Supplementation through the targeted absorption of micro-nutrients such as vitamins, minerals and from botanicals played a large part in his recovery.

As a result, at sense* we are more committed to the quality of the ingredients than we are to the bottom line.

Making sure our products contain the highest standards of ethically sourced, organic ingredients (where possible) without nasty fillers or bulking agents.

We insist on maintaining the highest levels of production of our products too, all of which are manufactured here in the UK to GMP standards.

 

Keyworker Charity Pledge

How often do you get the chance to give something back to others but help you and your family at the same time?  Perhaps when you do the shopping for an elderly neighbour as well as doing your own. Zinc‘d  is a bit like that. 

We are offering Zinc‘d at the lowest competitive price we can so that everyone can afford it. Why? Because we are on a mission to improve the immune health of the Nation.

To aid this mission, we want everyone to feel good about buying zinc‘d  . So ALL profits from zinc‘d sales during the pandemic will be donated to one or more keyworker charities.

Our mission is not about making money. It is about seeking to support the immune health of as many people as possible. Improving outcomes where possible for those most at risk.

And at the same time raising money for keyworkers or their families who have suffered loss because:

  • a keyworker has died as a result of COVID-19
  • a keyworker continues to be ill as a result of COVID-19

Learn more about how much profit will be donated in the FAQs below.

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Time to put you and your family first

A global pandemic focuses the mind on our health and whether we are looking after ourselves and our family properly.

Our immune system is amazing when treated well. It can even get by ok despite a poor diet or dodgy lifestyle choices. Until something new like Coronavirus comes along.

Since March sense* has advised its customers to focus on vitamins C & D plus zinc to top up their immune system.

Expecting the Government and Public Health England to provide a similar message, we waited and waited. Our Founder even started a Petition calling for more guidance. But no guidance has come!

So we made zinc’d, a new product named after the 3 key ingredients.  Do you like the name? We are quite proud of it 🙂  

zinc’d provides the 3 top supplements that your immune system needs, based on the weight of evidence of clinical trials (see What the Experts Say… below).

Many people are known to be deficient in one or more of these nutrients.

Below you will find details of why zinc, vitamin C and vitamin D3 are:

  • So important to your immune system functioning properly
  • The scientific evidence in support of each nutrient
  • How zinc’d provides the regular top up your body needs for its immune system

Why has Covid-19 been so Damaging in the UK?

You may have noticed that Europe and America have been worst affected by the Coronavirus pandemic in terms of number of cases and deaths. High on the list of contributing factors are being overweight and being either diabetic or pre-diabetic.

The Western diet of processed food, high in fats and carbohydrates and low in micronutrients is seen as a major contributor to a compromised immune system. Europe and America also has an ageing population and doesn’t get much sunshine in the winter. Not a great combo to fight off COVID-19!

As a result many of us are lacking in some of the essential nutrients needed to allow our immune system to function normally.

Even for those people who eat plenty of fruit and vegetables, the food consumed today contains a much lower level of nutrients than it did just 20 years ago because of modern farming, depletion of soil nutrients, use of pesticides and soil erosion.

Even the 5-a-day campaign turned out to be watered down. Because of the lack of nutrients in food, you actually need 10 portions-a-day of fruit and vegetables to take in the right level of nutrition. How many people are doing this?

 

Why take vitamins C & D and zinc?

The 3 ingredients in zinc’d are all essential to the normal function of the immune system:

zinc – zinc contributes to 300 chemical reactions in our cells helping to stop viruses reproducing. We can’t store it in our bodies so need to top up daily. It is only found in a few foods like salmon, mackerel, oysters and crab meat. And its absorption and retention can be further degraded by age and toxins such as alcohol or pollution.

vitamin C human beings are one of only a few species that don’t make their own vitamin C. We need to consume it everyday and when we do, we use it up quickly. 50% is used up in just 30 minutes. Failure to consume your 10-a-day of fruits & vegetables on a daily basis means we go through periods of deficiency that can affect our response to bugs and viruses.

vitamin D3 – surveys have found that vitamin D3 is deficient in up to 1 in 5 of the population, and more so in the elderly and BAME communities.  We do make our own vitamin D through exposure to sunlight. But our climate, recent lock-downs and work schedules mean that most of us do not make enough.

Jermaine Jenas (a former professional footballer and England player) acknowledged on BBC1’s the One Show recently that even though he was outdoors most of his working life training and playing football, he needed vitamin D supplements and still took them today.

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More About Zinc

Research tells us zinc affects our immune system in multiple ways. For example, it stimulates our T-cells, which are the cells that fight off illnesses such as viral and bacterial infections. 

As a result, if you are deficient in zinc, you may be more susceptible to colds, the flu or any number of infections like COVID-19.

Zinc  also boosts our immunity at the place of any inflammation such as a wound. Zinc is a known anti-oxidant too.  Helping to balance the immune system and fight inflammation.

Studies have highlighted the need for vitamins and trace minerals intake in order not to suppress the immune system response.  Not surprisingly, as a result a clinical  trial concluded that zinc supplementation reduced infections in the elderly. Another demonstrated zinc lozenges may reduce the length of the common cold.

See more details in “What the Experts Say” below.

More About Vitamin C

Vitamin C (known as ascorbic acid) is probably the most ‘popular’ of vitamin supplements. It is found in a variety of fruits and vegetables. Many people take it when they get a cold or flu.

Vitamin C is an anti-oxidant, helping to reduce free radical damage caused by bugs and viruses. So important when dealing with any infection – including CoVid-19. It reduces inflammation, improves healing and is vital for balancing the immune system.

Balance is important since it has been widely reported that over-reaction of the immune system causing cytokine or bradykinin storms has been one of the problems associated with Coronavirus.

Why do I need to take it? Humans are one of very few species that do NOT make our own vitamin C so we have to get it daily in the foods that we eat.  But half of it is used up within 30 minutes of consumption, so it needs to be consumed on regular daily basis to avoid short term deficiencies.

Most of us just don’t consume enough  foods rich in vitamin C to maintain optimal levels in our body. As a result, deficiency in vitamin C adds to the weakening of our immune system.

For more details, see “What the Experts Say” below.

More About Vitamin D3

We are all at greater risk of having a deficiency of vitamin D. Why?  Because we don’t get enough sunshine directly onto our skin which results in the creation of vitamin D. 

The elderly and those in the BAME community are particularly at risk, making even less vitamin D.

There are a number of other risk factors too that might cause low vitamin D in the body:

  • Restricted diet such as vegan or vegetarian
  • Mal-absorption in the gut such as coeliac or other condition
  • Reduced conversion in liver or kidneys due to medical conditions
  • Being overweight or obese
  • Not eating much fish or dairy.
  • Living far from the equator where there is little sunlight year-round
  • Always using sunscreen when going out
  • Staying indoors
  • Increased demand due to pregnancy or breastfeeding

Public Health England and the NHS recommends in normal circumstances that most people take a vitamin D supplement in the winter months and all year round if you don’t get out much at other times of the year.  These are not normal circumstances so even more reason to top up.

But make sure it is vitamin D3 and not D2 because vitamin D3 is 50% more effective than D2.

For more details, see “What the Experts Say” below.

What the Experts Say…

Zinc

“Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function…

Zinc deficiency is strikingly common….

affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors.

Consequently, zinc status is a critical factor that can influence antiviral immunity, particularly as zinc-deficient populations are often most at risk of acquiring viral infections.

From: The Role of Zinc in Antiviral Immunity. See Link 3.

“Since zinc boosts the overall immune response, all patients infected with the covid-19 virus would derive some benefit from zinc supplementation, especially those with latent zinc deficiency.

Antiviral activity for zinc has been shown in coronaviruses such as SARS-CoV, MERS and EAV viruses.

Zinc ionophores block the replication of these viruses in cell culture”

From: Zinc supplementation and containment of covid-19 virus pandemic. See Link 4.

“After zinc supplementation, the incidence of infections was significantly lower, plasma zinc was significantly higher, and generation of tumor necrosis factor alpha and oxidative stress markers was significantly lower in the zinc-supplemented than in the placebo group.”

From: Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. PubMed 2007. See link 11 below.

Vitamin C

“Vitamin C contributes to immune defence by supporting various cellular functions of both the innate and adaptive immune system…

Vitamin C deficiency results in impaired immunity and higher susceptibility to infections…

Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections.”

Vitamin C and immune function. PubMed, 2017. See link 7

“We found statistically highly significant evidence that vitamin C can shorten the length of ICU stay. We consider that our finding is a proof of concept, strongly encouraging further research..”

Vitamin C can shorten the stay in ICU. MDPI 2019. See link 8 below.

A well-functioning immune system is of the utmost importance to keep away the viral infection. And, vitamin C may support the defence against the COVID-19 virus, most importantly in chronically ill patients with a weakened immune system.”

Richard Cheng MD PhD (USA): Vitamin C saves Wuhan family from COVID-19. 2020

“In summary, we found that the addition of High Dose Intravenous Vitamin C may provide a protective clinical effect without any adverse events in critically ill patients with COVID-19. HDIVC provided one of the alternative treatment options, as there was no effective drug or treatment to cure COVID-19 at the present.”

High-dose vitamin C infusion for the treatment of critically ill COVID-19. To be peer reviewed. Wuhan University Hospital. October 2020. See link 12 below

“World’s best natural antibiotic, antiviral, antitoxin and antihistamine”.

Dr Andrew Saul PhD & editor-in-chief of the Orthomolecular Medicine News

“Can improve your general health, increase your enjoyment of life and help in controlling heart disease, cancer, and other diseases and in slowing down the process of ageing”.

Linus Pauling, two-time Nobel Prize winner

“vitamin C levels in Coronavirus patients drop dramatically when they suffer sepsis, an inflammatory response that occurs when their bodies overreact to the infection. ‘It makes all the sense in the world to try and maintain this level of vitamin C”

Dr. Andrew G. Weber, pulmonologist and critical care specialist, NYC, USA

Vitamin D3

Clinically, there is evidence of the association of vitamin D insufficiency and respiratory tract infections. There is also some evidence of the prevention of infections by vitamin D supplementation.”

Vitamin D, innate immunity and upper respirator tract infection.  See link 2 below.

“Vitamin D deficiency is correlated with a higher susceptibility to infections due to impaired localized innate immunity and defects in antigen-specific cellular immune response.”

Contribution of selected vitamins and trace elements to immune function.  PubMed 2007.  See link 1 below.

“Consider taking 10 micrograms of vitamin D a day to keep your bones and muscles healthy. This is because you may not be getting enough vitamin D from sunlight if you’re indoors most of the day.”

NHS website. See Link 6 below

“With the use of a daily dose of vitamin D relevant to public health recommendations (15 μg)…

vitamin D3 was more effective than vitamin D2 in increasing [blood levels] in the wintertime…

Vitamin D3 may therefore be a preferential form to optimize vitamin D status within the general population.

Daily supplementation with 15 μg vitamin D 2 compared with vitamin D3 to increase…hydroxyvitamin D status.. PubMed 2017.  Link 5 below

“Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19. Calcifediol seems to be able to reduce severity of the disease, but larger trials with groups properly matched will be required to show a definitive answer.”

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. NCBI October 2020.  See link 13 below.

“[Vitamin D] serum 25-hydroxyvitamin D (25OHD) levels are lower in hospitalized COVID-19 patients compared to population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease, although further studies including a large sample size should be done to determine the real
impact of vitamin D deficiency on the severity of COVID-19.”

Vitamin D Status in Hospitalized Patients With SARS-CoV-2 Infection. JCEM October 2020. See link 14 below

Zinc, vitamins C and D3 

“Although contradictory data exist, available evidence indicates that supplementation with multiple micronutrients with immune-supporting roles may modulate immune function and reduce the risk of infection. Micronutrients with the strongest evidence for immune support are vitamins C and D and zinc.” 

A review of micronutrients and the immune system. MPDI 2020. See link 9 below.

“Of the evidence, however, it was concluded that the largest body of evidence related to immune function existed for vitamin C, D and zinc. Hereon we subsequently focus on these nutrients with specific reference to the evidence on respiratory health.”

COVID-19 – Is there a role for immunonutrition, particularly in the over 65s? British Medical Journal 2020.  See link 10 below.

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FAQs – What Are The Most Important Questions?

Q – Does zinc’d cure Covid?

A – No, zinc’d is not a medicine and does not prevent, cure or treat any illness or disease including Covid-19.

Q – How much should I take?

A – The dosage of the product has been designed so that everyone can benefit by taking:

  • 1 capsule per day – If you are relatively healthy or not at risk of poor outcome from COVID-19
  • 2 capsules per day if you are at risk, see the size guide when you order

Double dosage in times of high demand, either if you are becoming ill or are taking more risk.  See the size guide on each product page when choosing your options.

Q – What size pack should I buy?

A – We have come up with a system where those who are relatively healthy only need one capsule per day, so 30 capsules per month.  Whilst those who are more at risk need 2 capsules per day, so 60 capsules per month.  That’s why zinc’d comes in 2 pack sizes: 30 capsules and 60 capsules.  Again, see the size guide on each product page when choosing your options.

Q – Do I need to take more capsules if I start feeling ill?

A- If your body is under attack and you feel ill or you are coming down with something.  Act quickly and double your dosage.  Your body will use up the ingredients at a much faster rate if you are becoming sick or unwell.

Q – What does one capsule of zinc’d contain?

A – A single capsule contains the following active ingredients:

  • zinc – at 12.5mg per capsule, is sufficient to top up your body’s immune system on a daily basis.
  • vitamin C – at 550mg per capsule.  Humans don’t make our own vitamin C nor do we store it. It is a major anti-oxidant and fights off infection and free radicals. So it is an essential vitamin that we must get from diet or supplementation.
  • vitamin D – at 10 micrograms per capsule. The Government recommends 10 micrograms daily for everyone over the winter and 20 micrograms for the elderly or non-mobile.

 

Q – Is taking 2 or more capsules needed?

A –  if you are at high risk which see the size guide when ordering.  Here is detail on each ingredient:

  • zinc – at 25mg per 2 capsules for those people at risk, you are maximising your requirement.  Any more than this on a long term basis and you run the risk of becoming anaemic.  However, on a short term basis up to 50 mg is within safety levels.
  • vitamin C – 1100mg in two capsules may result in sensitive individuals getting tummy groans and aches. However, most of us will be ok.  Taking higher doses is safe because you excrete any surplus that your body doesn’t need or use.
  • vitamin D –  the Government recommends  20 micrograms per day for the elderly which is contained in 2 capsules.

Doubling the dosage or even quadrupling (if taking only one capsule per day) in times of extra demand e.g. becoming ill, is a good idea since your body will use up much more nutrients in times of extra stress.

Q – What amount should I take if I’m already using other supplements?

A – If you are already taking some sense* products, we have always followed a simple rule and the same applies now. Because all the sense* products are powerful supplements with lots of nutrition, you shouldn’t take more than 3 dosages on a daily basis.

As far as zinc’d is concerned, your dose is dependant on your category, either at risk or not at risk. So if you are already taking 2 doses of other sense* products, either 2 x serving of one product or 1 x serving of 2 products, then you are allowed to take your suggested dose of zinc’d.

Q – Why are zinc’d products best on subscription or bulk buy?

A – We decided early on that zinc’d was going to be a subscription product.  In order to have the maximum impact across the population it is necessary to take these ingredients on a daily basis.  And if you forget, just double your dosage for a couple of days, it will only do you good.

However, we recognise that some people want either to have a decent supply in their cupboards or simply to grab a bargain.  So we have arranged for both the 30 capsule pack (one capsule a day – if not at risk) and the 60 capsule pack (two capsules per day – if at risk)  to be available as a bulk buy of 6 months(6 packs) or 12 months(12 packs).

Q – Which Keyworker charities will get the benefit of profits from zinc’d?

A – We have not yet fully decided on the keyworker charities to donate to. Sadly, there don’t seem to be a lot of options so we may have to set one up ourselves.  Watch this space!

Q – What amount of profit will be donated?

A – We will be donating all gross profit less direct overheads and expenses from the sale of zinc’d. This amount will vary based on the particular zincd product sold but can be estimated as being between £Nil –  £14.00 (based on production costs at launch).

Direct Overheads are all overheads or expenses or costs associated with the sale of  the sense* product known as zincd such as but not limited to advertising or marketing or personnel and includes:

  • any amount agreed for sense* to develop the logo, brand identity and fundraising plan on behalf of any not for profit entity seeking grants from sense*
  • any amount added back by HMRC as a benefit which reduces corporation tax relief including but not limited to use of charity logos, identity or other deemed benefits

Q – Who will be included as keyworkers and eligible for grants?

A – We have used a definition for keyworkers originally produced by the Cabinet Office.  We want everyone to benefit from the lowest paid to the top consultants.

Q – Why does sense want to benefit individual keyworkers?

A – Individual keyworkers seem to have got a raw deal.  Lots of clapping (for a while) and lots of donations to NHS charities.

But donations to NHS charities don’t reach individual keyworkers or their families, they go to the NHS institutions.  If we were being cynical these donations simply end up in Government coffers.

So there is a need to put this right, wouldn’t you agree?

Q – How to help protect ourselves against illness?

A – Viruses and humans come into contact every day. For the most part they are harmless or dealt with by our immune system. But they can have varying impacts on us and from the time we are born we build immunity to many of them through contact in our daily lives.

As we age, or compromise our immune system through diet and lifestyle or lack of mobility, our reaction to viruses becomes weaker.

We can under respond, or in some cases reported for COVID-19, we can over respond resulting in cytokine or bradykinin storms. An over response means that our immune cells continue to attack our good cells even if the bug or virus has been dealt with.

These cytokine or bradykinin storms can be as deadly as the virus itself. A balanced immune system, working normally has a better chance of reacting in a more positive way.

Q – What do we know about Coronavirus?

A – We know this is a new virus that has crossed the animal to human barrier. It attacks the organs of the body, predominantly the lungs but has also been seen to attack other organs.

What is also becoming more apparent is that the after affects of COVID-19 can be debilitating. Long COVID, as it has become known, is now a serious threat to long term health in many people.

Being ‘new’ to humans, we have no acquired immunity so everyone is at risk of infection. Without a vaccine, it is likely a large proportion of the population will get it in some form or another.

With only a few treatments against the infection, it comes down to each individual’s own immune response to determine how badly a person is affected. How do you personally try to improve the performance of your own immune system?

Q – Who is most at risk from COVID-19 & Why?

A – Data suggests that the most likely people to suffer the most severe reactions are the elderly, the overweight or diabetic or those people suffering with existing heart conditions or who have been immune compromised by cancer treatments such as chemotherapy or radiation.

In addition, through poor dietary choices or living in deprived areas, many of the poorest in society have had bad outcomes.

Through no fault of their own, members of the BAME community have also been badly affected. Potentially, as a result of any one of the above reasons. But in addition, there could be a direct link to the fact that members of the BAME community do not make as much vitamin D as other groups.

All these diverse groups of people can be described as having a weakened or compromised immune system.

This would suggest that the key to achieving a good outcome should a person get coronavirus, or any other virus or bug is optimizing and maintaining a healthy immune system.

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